The Aqua Cure clue is something you need to use to open the Resident Evil 3 safe in the Drugstore.
You learn about this by reading the Drugstore Owner's Journal File, though there is seemingly nothing nearby to hint at what the Aqua Cure is.
We explain how to work out the Aqua Cure clue, and if you just prefer to find out the answer, how to open the Drugstore safe. It's not the easiest puzzle to solve, but the reward inside is worth it!
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Looking for something else? Visit our Resident Evil 3 walkthrough for more help.
Where to find the Aqua Cure safe clue in Resident Evil 3
When you visit the Drugstore for the first time while searching for the Fire Hose, you'll find a locked safe and the Drugstore Owner's Journal File, which refers to the Aqua Cure as away to open it.
This room (aside from a single Bobble Head location and some consumables) has nothing else of use, so you need to look elsewhere.
To work out the Aqua Cure clue, you need to leave the Drugstore and head west towards the Subway Offices.
On this street at the end is a Pharmacy, an optional location you visit.
This where you can find an Aqua Cure poster on the back wall, with the three numbers circled.
Resident Evil 3 Aqua Cure safe code solution
Using this clue, the code for the Aqua Cure safe is 937 - which means you have to move the safe dial Left 9, Right 3, Left 7.
Remember - this refers to the direction of the safe dial, and not what you need to press to move it, which is actually the opposite.
By the way - this is different to the safe code seen in the demo - so don't expect that to work here!
Inside the safe is the Dot Sight (Handgun) weapon upgrade, which you can combine to upgrade the weapon. Useful!
With that done, there are plenty of other things to find in this opening area of the game - which our Resident Evil 3 walkthrough can help with.