Agarest: Generations of War Zero
Unnatural selection.
Agarest: Generations of War Zero is a game about heredity. In the first half of the game you play as Sieghart, a typical tousle-haired anime hero sort, as he fights monsters and decides which of his many female companions he'd like to romance. In the second half of the game, you play as their offspring, with abilities and stats determined by the parental choices you made earlier.
However, Agarest is also a cautionary tale about the perils of limited genetic diversity. Far from being a sturdy hybrid, able to survive a changing environment, it's an inbred throwback, too indebted to a shallow gene pool to truly impress.
Tactical role-playing is the genre, and it's an area that has hardly benefited from much cross-breeding in recent years. There have been occasional flurries of innovation, but otherwise it's a gameplay style that is still much the same as it was in the time of Tactics Ogre and Vandal Hearts.