You can get the general gist of things as you go along but some of the fundamental rules such as "force outs" and "tagging up" are not necessarily explained in the game iirc and you need to have a handle on these to enjoy a full match or career.
They're pretty simple, but occasions can arise when they can be complex.
To be honest, you'll get enjoyment from batting practice and the Home Run Derby, but be warned it can be frustrating when you continually strike out in games. Thankfully there are sliders, no baseball pun intended, all over the shop to make things easier.

