If you were one of the thousands who heeded Kristan's wise words and bought a copy of BioShock on release, rocketing the game to the top of the all-format charts in the process, then you've probably already experienced the wonders of Rapture and are currently playing through again on a higher difficulty. If so then this guide to every Plasmids and Gene Tonic in the game - where to find them and what they do - was written with your good self in mind. If not, be warned - there be big spoilers ahead.
Note: For Plasmids and Gene Tonics available from Gatherer's Garden machines, only the location where you can first buy them is listed, yet they'll be available from every machine from that point on. In addition, some Tonics hidden in the wild can later be purchased from Gatherer's Garden machines for a small amount of Adam, so don't worry if you miss them first time round.
Easily the most useful Plasmid power in the game. Use it to stun Splicers, stopping them in their tracks so you can attack them with a good old fashioned weapon. And it's a nice surprise for enemies stupid enough to stand in water. Electro Bolt is also vital for frazzling security devices and opening dodgy doors. Dedicate a slot to this Plasmid and upgrade as and when you can. You'll grab the standard Electro Bolt right at the beginning of the game, by the Gatherer's Garden machine at the top of the stairs. For longer lasting shock treatment you should definitely purchase Electro Blot 2 (120 Adam) from Gatherer's Garden machines in Arcadia, and Electro Bolt 3 (150 Adam) from machines in Olympus Heights.
Like Electro Bolt, this Plasmid is essential for progressing through the game as it lets you melt frozen doors. Of course you can also use it to torch enemies, either directly or by igniting pools of oil or explosive canisters. Some enemies will battle on even when blazing so be ready to follow up with an alternative attack. Incinerate is located in the Medical Pavilion area, inside the Eternal Flame crematorium - crawl through the small hole in the wall on the upper floor to find it. Incinerate 2 offers increased heat and can be vended from the machines in Fort Frolic for 80 Adam. Later, when you reach Point Prometheus, you can upgrade to the toastiest temperature, Incinerate 3, for 150 Adam.
Great for grabbing items just out of reach, and ideal for those Carrie White moments when you just want to hurl stuff at those who hassle you. Also useful for plucking missiles and grenades out of the air and returning them to sender (hello Nitro Splicers!). Telekinesis is located in the Medical Pavilion area, inside the Dandy Dental clinic. It's not possible to upgrade this Plasmid.
Hit an enemy with Enrage and they'll fight the good fight for you. Great if there are groups of enemies and you want to encourage a little infighting, even better if you're taking on a Big Daddy as you can enlist the help of Splicers. Enrage is not found in the wild, but you can buy it from a Gatherer's Garden machine in the Medical Pavilion for 60 Adam. It can't be upgraded.
Whack this on the back of an enemy and if they're in range of a sentry system it will target them instead of you. Neat but not essential as you can always hack security devices. It's located in Neptune's Bounty, inside the Wharfmaster's Office. No upgrades are available.
If you like to play a more measured game than an all-out assault, you can use Target Dummy to fool enemies and draw their fire. This handy decoy lasts for around 10 seconds, enough time to flank your enemy or simply flee the scene. Very useful for stealing a march on a Big Daddy. Target Dummy is available from Gatherer's Garden machines in Neptune's Bounty for 60 Adam.
This three-tiered Plasmid will freeze common enemies for a few seconds, letting you shatter them dead. However, while it's a nice quick kill method, the enemy won't leave behind any goodies so it should be used sparingly. You can also use it on devices to increase the time available for hacking. The standard Winter Blast can be vended from machines in Neptune's Bounty for 60 Adam, while the two upgrades are available later in the game - Winter Blast 2 in Fort Frolic for 100 Adam, Winter Blast 3 from Olympus Heights for 150. Each successive upgrade simply increases the time that enemies stay iced up.
Invoke mini tornadoes that lift enemies clean off their feet and bring them crashing to the ground with a pleasing crack. This sits alongside Target Dummy as a Plasmid for those who like to play with guile and lay traps. Don't miss the opportunity to shoot enemies when they're flapping around in the air. Both varieties of Cyclone Trap are available from machines in Arcadia - the first for 60 Adam and the second more turbulent version for 100.
Splicers don't carry around rolled-up newspapers so a swarm of stinging bees will certainly inconvenience them. It's a good laugh for sure, and useful against groups as the bees will swarm around several enemies, but it's no substitute for the trusty Electro Bolt. If you do want it, pick up the standard Plasmid from machines in the Farmer's Market for 60 Adam. Insect Swarm 2 and 3, which breed successively angrier insects who swarm harder and longer, are available from Hephaestus (80 Adam) and Olympus Heights (120 Adam) respectively.
Hypnotize Big Daddy
Why should only Little Sisters get an armed escort? This Plasmid will enlist a Big Daddy as your personal bodyguard for a short period of time, which obviously is a very good thing (and as an added bonus, great for Big Daddy research purposes). This is the only Plasmid that can't be found in the wild or purchased with cold hard Adam. To get the standard Plasmid, where a Big Daddy will guard you for a minute and a half, you must rescue three Little Sisters rather than harvest them. You'll receive the upgrade, which affords a full three minutes of Big Daddy protection, if you rescue nine of the poor dots.
Combat Gene Tonics
Reduces the amount of damage you receive, making this a highly-desirable Gene Tonic. Even better, you can get it as early as the Medical Pavilion from a Gatherer's Garden machine for 20 Adam. If you manage to rescue 15 Little Sisters you'll unlock Armored Shell 2 which offers increased shield-like properties.
Dishes out more than three times the brain-bludgeoning power of the standard Wrench - great for melee fans and ammo conservationists. Get this from the Kure-All clinic in Medical Pavilion (look for the secret passageway hidden behind a grate). The Wrench Jockey 2 upgrade is offered to you when you research Big Daddy Bouncers to Level 2.
Another Tonic for Wrench wielders. If you're struck while scrapping you'll automatically give the enemy an energy-sapping shock for their troubles. You'll find this next to a corpse in the Surgery Foyer, either before of after you deal with Doctor Steinman. Static Discharge 2 is a free upgrade that you get for researching Leadhead Splicers to Level 4.
For stealth fans only - increases the amount of damage inflicted by the Wrench on unaware enemies. As an added bonus it also softens your footsteps. Grab this from Lower Wharf, Neptune's Bounty. For extra sneakiness you can buy Wrench Lurker 2 from a Gatherer's Garden machine later in the game.
Increases the amount of damage delivered by flame attacks, making it an ideal companion to the Incinerate Plasmid. It also rather handily reduces the amount of damage that you receive from fire and heat. Available from Gatherer's Garden machines (Arcadia), as is the fiery upgrade from Point Prometheus onwards.
Makes photos fill your research bar slightly quicker. You'll find this in the wild, down in the Winery Cellar in Farmer's Market. The upgrade is given to you when you research Big Daddy Rosies to Level 2.
An electro-version of Human Inferno. Find it in Fort Frolic, up in the Fleet Hall Theatre's projection booth after finishing Cohen's 'masterpiece'. Electric Flesh 2 can be found in Fontaine's Apartment, Olympus Heights.
As above, only it affects ice attacks and should be combined with the Winter Blast Plasmid. Get this from the Frozen Tunnel, Fort Frolic (it's found on Finnegan's body). You'll find the upgrade outside the office of Andrew Ryan in Rapture Central Control.
Increases the damage bonuses you earn through research, and therefore essential if you're going to put in all the hard work snapping baddies. Found in the Lower Workshops, Hephaestus. Damage Research 2 boosts damage bonuses even more and is available late in the game from the Mendel Library, Point Prometheus.
Physical Gene Tonics
An essential Tonic. Supplies you with EVE every time you replenish you health with a first aid kit. Get it from any Gatherer's Garden machine (Medical Pavilion) for just 20 Adam. EVE Link 2, which provides even more EVE per kit, can be found in the wild as you first enter Farmer's Market.
Supplements your health every time you successfully hack a device. You'll find it in the Medical Pavilion area, inside the Eternal Flame crematorium - fire up the furnace then search the ashes. The two upgrades give you additional health. Hacker's Delight 2 can be made at U-Invent machines (Fort Frolic), while Hacker's Delight 3 is located in Point Prometheus, inside Failsafe Armored Escorts.
You'll receive a small health boost when you eat. Get the standard Tonic from a Gatherer's Garden machine (Neptune's Bounty) for 20 Adam. For what it's worth, Extra Nutrition 2 can be found in the wild, inside Sinclair Spirits (Fort Frolic) - you need to use the switch behind the counter to access the secret stairs outside. Extra Nutrition 3 is given to you if you research Spider Splicers to Level 4.
Gives you an additional health boost when you use first aid kits. You'll find the standard Tonic in Lower Wharf, Neptune's Bounty. The two upgrades are both found in the wild - the first in Fort Frolic (given to you by Sander Cohen) and the second in Doctor Suchong's Clinic in Apollo Square.
Causes security devices to delay seeing you for a few seconds. It's found near to Waterfall Grotto, Arcadia. Security Evasion 2 increased the delay further and can be found in Lower Heat Loss Monitoring, Hephaestus. It's a useful Tonic to have later in the game when the security steps up a notch.
You'll receive both health and EVE when you whack somebody with the Wrench, making this a very useful Tonic. It can be made at U-Invent machines (Fort Frolic).
Instead of losing EVE when you drink alcohol, with Booze Hound you actually gain some. Like Bloodlust, you can mix this together at U-Invent machines (Fort Frolic), although the ingredients should really be used on something that's actually useful.
Increases the speed at which you rush and attack with the Wrench. Given to you if you research Thuggish Splicers to Level 2, with the speedier Sportboost 2 rewarded when you reach Level 4.
Lets you search corpses again to find different stuff, which may be better or worse than your original find. To get it research Leadhead Splicers to Level 2.
A fine, fine Tonic that allows you to blend into the background when you stand still, making you invisible to enemies and security systems. Research Houdini Splicers to Level 2 and it's yours.
Engineering Gene Tonics
Makes hacking devices easier by slowing down the liquid flow and removing troublesome tiles. Found in Twilight Fields, Medical Pavilion. You'll received Security Expert 2 if you research Security Bots to Level 2, although it's worth pointing out that if you reach Level 4 then all hacks automatically succeed anyway.
Slows down the liquid flow speed when hacking. Get this from the Painless Dental clinic in the Medical Pavilion. If you really can't hack it then buy the improved Speedy Hacker 2 from Gatherer's Garden machines (Olympus Heights).
Reduces the amount of time that alarms sound for. Found in the Neptune's Bounty area, on the top floor of Fighting McDonagh's - enter 7533 to unlock the door with the combination lock and then listen to the Audio Diary inside. Shorten Alarms 2 does exactly what you'd expect and can be found on the lowest floor of Geothermal Control, Hephaestus.
Reduces the number of Overload tiles when playing the hacking mini-game. Found inside ice at the entrance to Fontaine Fisheries, Neptune's Bounty. Focused Hacker 2, which removes even more Overload tiles, is located on the fourth floor of Hestia Chambers, Apollo Square.
As above, only this Tonic removes both an Overload and an Alarm tile. You'll find it as you enter the Research Labs in Arcadia. The upgrade removes two of each tile and can be bought from a Gatherer's Garden machine (Fort Frolic) for 50 Adam.
Another non-essential hacking tool. This one removes only Alarm tiles. Find it on the leftmost balcony inside Fleet Hall Theatre, Fort Frolic. Alarm Expert 2 is found later on inside Optimized Eugenics, Point Prometheus.
A must-have Tonic that reduces the quantity of each ingredient required to make stuff at U-Invent machines by one. And by hacking the machine you can reduce the quantity by one again. Make sure you grab this from Suchong's Apartment in Olympus Heights.
For every item you create at the U-Invent machines you get double. Great for stocking up on rare and powerful ammo. You get this for rescuing 18 Little Sisters.
Like the Security Expert Tonic, only specifically for hacking safes and locks. Rescue six Little Sisters to receive this. The upgraded Safecracker 2 can be found in the lower room of the Educational Facility in Point Prometheus.