Guillermo del Toro and Volition's 2013 horror game inSANE is the first chapter in a planned trilogy.
Publisher THQ has signed del Toro in a multi-year agreement to create the trilogy.
Del Toro will serve as external creative director for the games, working closely with THQ core games boss Danny Bilson and Saints Row developer Volition.
inSANE will deliver an "unprecedented cinematic experience while redefining storytelling in gaming" THQ said today.
THQ said del Toro and the publisher will collaborate on "potential transmedia projects surrounding the inSANE games".
THQ will own the intellectual property rights to the inSANE games, and del Toro will hold the rights to any filmed entertainment products.
Del Toro formerly announced inSANE at the Spike Video Game Awards with a teaser trailer, below. "Hopefully you'll shit in your pants," the director said on stage.
"THQ is committed to creating great games by identifying the world's most talented artists and providing them with the creative support to design innovative gameplay experiences," commented Bilson.
"Guillermo is not only an incredibly gifted writer and film director, but also an avid gamer, and we are excited to bring his talents to our medium. We are confident his unique point of view will create visually stunning adventures, filled with rich and rewarding gameplay."
"With this new series of videogames, I want to take players to a place they have never seen before, where every single action makes them question their own senses of morality and reality," offered the Pan's Labyrinth director.
"THQ and Volition, Inc. are equally excited to make this vision of a completely new game universe into a reality."
In September del Toro described inSANE as a "Lovecraftian" horror game.
"We are talking about huge games, huge world creation and long deadlines," he said
"With THQ we're looking at around a three year developing deadline for each game. Big games. More details forthcoming, but we are truly exploring them in a serious manner. Expect the first game, best-case scenario, 2013.
"It's horror...but it's a very different type of horror game. It's not survival horror. It's truly a strange, geeky mix. It's a Lovecraftian thing. Let's leave it at that."
On the night of the VGAs, THQ core games boss Danny Bilson Tweeted, "Finally announced inSane! Been workin with GDT for 6 months. Just finished the story beats yesterday. An Horrific Adventure for 2013."